Practical training and experience, for a period of not less than 5 years, must be related to Toxicology. Training will usually be on the job, based on laboratory, clinical, computer assisted or regulatory work. In some cases, toxicologists will undertake research and be based in a single department / under a single named mentor: candidates for registration are advised to ensure at the outset that their intended course of study is seen, by a senior ERT or member of the National Register, as appropriate and applicable to the eventual target of Registration.
A candidate for Registration will be expected to have obtained Practical Awareness (knowledge of major techniques and their merits and limitations, not necessarily hands‐on experience) in the topics listed below. In addition, an in‐depth knowledge and experience will be expected in at least two of them:
C1. Post-mortem methods, animal or human pathology and histology. Microscopic recognition of the major pathological processes. Foetal and neonatal examination for malformations.
C2. Making observations and records of signs in animals or humans. Humane dosing, sampling and euthanasia of animals; in vivo monitoring, biomonitoring, biomarker studies on animals or humans. Prevention, diagnosis and treatment of acute or chronic chemical exposure and poisoning.
C3. Principles and techniques of cell culture. Testing for compound effects on cells in culture, including applied methodology such as the Ames Test; recognition of basic chromosomal aberrations, blood film analysis, subcellular fractionation techniques.
C4. Computer-aided technologies in toxicology. (Quantitative) structure-activity relationships, read-across, calculations of toxicity and biokinetics/dynamics (PBPK/TD) and computational structural biology.
C5. Standard analytical methods and techniques, e.g. spectrophotometry, gas and high performance liquid chromatography, mass spectrometry; biochemical and molecular techniques: e.g. protein determination, enzyme activity, blotting and antibody-based techniques, radiochemistry, Reverse-transcriptase (RT) and Real time (RT)-polymerase chain reaction (PCR), “omics” techniques.
C6. Design of experiments, biometric and statistical procedures. Data retrieval, data derivation, computer-assisted technologies, data-bases, data-banks, and data acquisition.
C7. Determination of pharmacokinetic parameters and compound metabolism.
C8. Procedures in risk analysis (risk assessment, management and communication), regulatory toxicology, data reliability and relevance, risk-assessment experience under mentorship.
Documentation of practical experience, Communication skills, Authorship
Candidates for registration will have documented their practical experience by at least 5 confidential reports, assessments, or publications. Reports and assessments should be suitable for submission to regulatory agencies or for regulatory decision‐making. Publications should have appeared in peer‐reviewed scientific journals. It is regarded as essential that these papers demonstrate a high standard of critical ability and communication skills. Critical ability and communication skills can be documented further by a record of oral presentations and through authorship of written reviews and a dissertation / thesis. Examples should be included with any application for Registration.
For all the above mentioned the candidate for registration will be expected to provide written confirmation from relevant supervisors who are also prepared to act as sponsors.